Male erectile dysfunction (ED) or those prescribed from birth is treated with both Tadalafil Vs. Sildenafil (AMAB).

While Sildenafil is better recognized under the trade name Viagra, tadalafil is more often known under the name Cialis.

In the US, erectile dysfunction is quite prevalent. Approximately 30 million men in the US struggle with erection issues.

These two salts fall under the category of oral drugs, which are among the several therapies available for erectile dysfunction.

We shall learn the distinction between Tadalafil and Sildenafil from this article.

Which is preferable, sildenafil or tadalafil?

Selecting between Tadalafil and Sildenafil might be challenging because of their almost identical mechanisms of action and effects.

These two salts are inhibitors of phosphodiesterase type 5 (PDE-5).

They work by blocking the PDE-5 enzyme in the penile region to cure erection issues. The penis receives more blood flow because to this inhibition.

To help you decide which erectile dysfunction medication is superior, we’ll outline the main variations between Tadalafil and Sildenafil.

How much time do Tadalafil and Sildenafil last?

While the effects of Tadalafil persist longer, those of Sildenafil only endure for 4 to 5 hours.

Tadalafil medications are referred to as the “weekend pill” by many because of its enduring effects.

As per a study, males can take the tablet on Friday night and continue using it on Sunday morning because of its average 36-hour duration.

Which is more efficient:

Tadalafil or sildenafil Tadalafil may take between fifteen minutes and two hours to start working. Conversely, Sildenafil starts to work 30 minutes after ingesting it.

Large meals and alcohol do not influence Tadalafil absorption, however they may slow the absorption of Sildenafil.


For optimal effects, take sildenafil empty-handed, or just before or after a small meal, as recommended by

Side effects of sildenafil versus tadalafil

Head Pain 

Side effects from sildenafil and tadalafil are frequent. These consist of:


Head Pain


upset stomach in

Priapism is an uncommon adverse effect of these pills.


Get medical care right away if you suffer from any severe adverse effects.

The occasional occurrence of aberrant eyesight is the distinction between the side effects of sildenafil and tadalafil.

It is possible for sildenafil and tadalafil to result in blindness or visual loss.

However, sildenafil may also result in alterations to eyesight, such as heightened light sensitivity and trouble telling the difference between green and blue.

Another distinction is that Tadalafil usage is linked to adverse effects such muscular or back discomfort, whilst Sildenafil is not known to have these symptoms.

Sildenafil vs. Tadalafil dosage

The Food and Drug Administration (FDA) has authorized Tadalafil in four distinct dosages: 2.5 mg, 5 mg, 10 mg, and 20 mg.

Furthermore, generic Tadalafil tablets in 60 mg dosages are available.

However, sildenafil dosages exist in three different forms:

50, 100, and 25 milligrams.

Nonetheless, 200 mg of sildenafil tablets are frequently given.

Depending on the severity of your ailment and how you respond to therapy, your doctor can determine the maximum amount you can take each day.

Tadalafil vs Sildenafil: Key differences

What is its working speed?The effects of tadalafil may not appear for 15 minutes to 2 hours.Within half an hour of ingestion, sildenafil begins to act.
What is the duration of the effects?The impact might linger for up to 36 hours.Only four to five hours pass during the impacts.
Side effectsIn addition to other typical adverse effects, muscle or back discomfort.In addition to typical side effects, it could result in aberrant eyesight.

In summary

Even after learning the distinction between Sildenafil Vs Tadalafil, confusion may persist.

This is due to the fact that sildenafil and tadalafil function similarly and have comparable effects.

A research by International Urology and Nephrology found that Tadalafil is preferred by most patients and their spouses because to its longer duration of usage.

However, you still need to decide between Tadalafil and Sildenafil as an erectile dysfunction medication.

A medical expert can assist you in selecting the drug that is best for you depending on your diagnosis and symptoms.

It is advised to see a doctor or other healthcare provider because of your existing medical condition and the possibility of adverse consequences. Do not self-medicate.


AMB: A male allocated at birth.

The inability of males to get or keep an erection long enough for sexual activity is known as erectile dysfunction.

PDE-5 Inhibitors: These medications alter blood flow and the body’s cell-to-cell communication. PDE-5 medications stop PDE-5 enzymes from functioning by blocking them.

An erection lasting more than four hours is referred to as prurism. It occasionally may also result in excruciating erections.

Answers to Common Questions

Does Tadalafil wear off faster than Sildenafil?

No, Tadalafil still has the same half-life as Sildenafil. While the effects of sildenafil only last four to five hours, those of tadalafil can last up to 36 hours.

Which is preferable, Tadalafil or Sildenafil?

There is no better drug than tadalafil or sildenafil because they both have the same medicinal effects.

Tadalafil is preferred by the majority of patients due to its longer-lasting benefits and less chance of adverse effects. Since tadalafil is usually taken at lower quantities, there may be a relationship between the decreased risk of adverse effects and this.

To choose the best drug for you depending on your symptoms and diagnosis, you can speak with your doctor.

Does Tadalafil have to be taken daily?

Research indicates that using Tadalafil on a daily basis is safe. To ensure that your therapy is effective, you must adhere to your doctor’s recommendations.